<p class="jove_content">Infection of neonatal mice with bioluminescent <em>E. coli</em> O1:K1:H7 results in a septic infection with significant pulmonary inflammation and lung pathology. Here, we describe procedures to model and further study neonatal sepsis using longitudinal intravital imaging in parallel with enumeration of systemic bacterial burdens, inflammatory profiling, and lung histopathology.</p>

a-neonatal-imaging-model-of-gram-negative-bacterial-sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Neonates are at an increased risk of bacterial sepsis due to the unique immune profile they display in the first months of life. We have established a ...

Institution - Vaccine Development Center at West Virginia University Health Sciences Center

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